Anti-LPAR5 / Lysophosphatidic acid receptor 5

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. LPAR5 antibody detects Lysophosphatidic acid receptor 5, a G protein-coupled receptor (GPCR) that mediates signaling by lysophosphatidic acid (LPA), a bioactive phospholipid involved in cell proliferation, motility, and immune regulation. The UniProt recommended name is Lysophosphatidic acid receptor 5 (LPAR5). This receptor couples primarily to G12/13 and Gq proteins, triggering downstream activation of Rho and phospholipase C pathways.Functionally, LPAR5 antibody identifies a 353-amino-acid receptor localized to the plasma membrane. LPAR5 activation induces calcium mobilization, cytoskeletal rearrangement, and cytokine release. It contributes to pain sensation, vascular permeability, and immune cell migration. In neuronal cells, LPAR5 influences axonal guidance and neuroinflammation.The LPAR5 gene is located on chromosome 12p13.31 and is expressed in platelets, lymphocytes, dorsal root ganglia, and intestinal epithelial cells. It plays roles in both physiological and pathological processes such as wound healing, sensory transmission, and inflammation.Pathologically, dysregulation of LPAR5 signaling has been implicated in neuropathic pain, cancer metastasis, and autoimmune diseases. Inhibition of LPAR5 reduces pain hypersensitivity and inflammatory cytokine production, making it a potential therapeutic target. Research using LPAR5 antibody supports studies in GPCR signaling, lipid biology, and inflammation.LPAR5 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect LPA receptors. NSJ Bioreagents provides LPAR5 antibody reagents optimized for research in lipid signaling, receptor pharmacology, and immune modulation.Structurally, Lysophosphatidic acid receptor 5 contains seven transmembrane helices and intracellular loops that couple to G proteins and scaffolding proteins. This antibody facilitates exploration of LPAR5's signaling mechanisms and receptor-mediated physiological responses.