Anti-LFA-3/CD58 Rabbit Monoclonal Antibody (Clone 126)

Lymphocyte function-associated antigen 3 (LFA-3), also known as CD58, is a membrane-associated glycoprotein. It exists as two isoforms: a type I transmembrane glycoprotein involved in signal transduction and a glycosylphosphatidylinositol-anchored (GPI-anchored) form primarily involved in cell adhesion. A soluble form of LFA-3, sCD58, also exists. Transmembrane LFA-3 is composed of an N-terminal extracellular domain containing N-linked glycosylation sites, a transmembrane domain, and a short C-terminal cytoplasmic tail. The GPI-anchored form is located extracellularly and is linked to the plasma membrane via the C-terminus. LFA-3 is expressed broadly on hematopoietic and non-hematopoietic cells and its ligand, CD2, is expressed on T cells, natural killer (NK) cells, thymocytes, and certain bone marrow cells. LFA-3 acts as a co-stimulatory receptor that, when bound by CD2 on the surface of T cells, is part of the immunological synapse and induces T cell activation. It is also involved in thymocyte development and NK cell communication, as well as other immune and non-immune functions. sCD58 disrupts cell-cell adhesion and has immunosuppressive effects. Various SNPs in CD58 are associated with an increased risk of multiple sclerosis with one SNP potentially conferring a protective effect. The expression of CD58 is increased or decreased in various cancers with increased expression positively correlated with overall survival and disease-free survival in patients with acute myeloid leukemia (AML). Cayman's LFA-3/CD58 Rabbit Monoclonal Antibody (Clone 126) can be used for immunohistochemistry paraffin (IHC-P).Synonyms: Ag3, Lymphocyte Function Antigen 3, Lymphocyte Function-associated Antigen 3, Surface Glycoprotein LFA-3. Immunogen: Recombinant human LFA-3/CD58. Clone Designation: 126. Formulation: (Request formulation change), 50 or 100 µl of protein A-purified monoclonal antibody. Storage Buffer: 0.2 µm filtered solution in PBS. Host: Rabbit. Isotype: IgG. Applications: IHC-P. Cross Reactivity: (+) CD58.