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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-20B-6002PF-C100 | 100 µg | - |
3 - 9 business days* |
429.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Membrane glycolipids represent an unexplored source of tumor-associated antigens. Many of these... more
Product information "Anti-Lewis y/b hapten (human), clone SC104 (preservative free)"
Membrane glycolipids represent an unexplored source of tumor-associated antigens. Many of these are overexpressed and altered in tumors compared to normal tissue. Research into aberrant glycosylation and over-expression of glycolipids on the surface of the majority of cancers, coupled with a knowledge of glycolipids as functional molecules involved in a number of cellular physiological pathways, has provided a novel area of targets for cancer immunotherapy. Lewis-y/b is a cell surface carbohydrate blood group antigen expressed at very low levels in normal tissue, but often found to be overexpressed on breast, lung, colon and ovarian cancer cells. Clone SC104 recognizes a unique cell surface antigen sialyltetraosylceramide, expressed by 90% of colorectal tumors at all clinical stages. SC104 targets colorectal cancer-associated glycolipids and induces tumor cell death in vitro independently of CDC or ADCC or blockade of known survival signaling pathways. It induces apoptotic cell death and synergizes with chemotherapy in vivo in mice.
Keywords: | Sialyltetraosylceramide, NCRC37 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-20B-6002PF |
Properties
Application: | ELISA, FC, FA, ICC, IHC |
Antibody Type: | Monoclonal |
Clone: | SC104 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Tissue cultured colorectal tumor cell lines (C170, C146, Colo205 and JW) |
Purity: | >95% |
Format: | Purified |
Database Information
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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