Anti-LEF1

Anti-LEF1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-486A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-486A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-486A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Participates in the Wnt signaling pathway. Activates transcription of target... more
Product information "Anti-LEF1"
Protein function: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1- independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. [The UniProt Consortium]
Keywords: Anti-LEF1, Anti-LEF-1, Anti-TCF1-alpha, Anti-Lymphoid enhancer-binding factor 1, Anti-T cell-specific transcription factor 1-alpha
Supplier: Bethyl Laboratories
Supplier-Nr: A303-486A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Rat)
Immunogen: synthetic peptide. The epitope recognized by A303-486A-T maps to a region between residue 250 and 300 of human Lymphoid Enhancer-Binding Factor 1 using the numbering given in entry NP_057353.1 (GeneID 51176).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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