Anti-LEF1

Item number	Size	Manual	Delivery time	Price
A303-486A-T	20 µl (2 blots)	-	3 - 9 business days*	131.00€
A303-486A-M	100 µl (10 blots)	-	3 - 9 business days*	313.00€
A303-486A	100 µl (100 µg)	-	3 - 9 business days*	465.00€

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Protein function: Participates in the Wnt signaling pathway. Activates transcription of target... more

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Product information "Anti-LEF1"

Protein function: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1- independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. [The UniProt Consortium]

Keywords:	Anti-LEF1, Anti-LEF-1, Anti-TCF1-alpha, Anti-Lymphoid enhancer-binding factor 1, Anti-T cell-specific transcription factor 1-alpha
Supplier:	Bethyl Laboratories
Supplier-Nr:	A303-486A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Reactivity:	Human (Expected: Mouse, Rat)
Immunogen:	synthetic peptide. The epitope recognized by A303-486A-T maps to a region between residue 250 and 300 of human Lymphoid Enhancer-Binding Factor 1 using the numbering given in entry NP_057353.1 (GeneID 51176).
Format:	Antigen Affinity Purified