Anti-LAT / Linker for activation of T-cells family member 1

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. LAT antibody detects Linker for activation of T-cells family member 1, encoded by the LAT gene. Linker for activation of T-cells family member 1 is a transmembrane adaptor protein expressed in T cells and natural killer cells, where it serves as a central scaffold for antigen receptor signaling. LAT antibody provides researchers with a critical reagent for studying T cell receptor signaling, immune responses, and related diseases.Linker for activation of T-cells family member 1 localizes to lipid rafts in the plasma membrane. Research using LAT antibody has shown that upon T cell receptor stimulation, LAT becomes tyrosine-phosphorylated by ZAP70. These phosphorylated residues recruit multiple signaling proteins, including GRB2, PLCG1, and GADS, forming a large signaling complex. This assembly drives calcium signaling, MAPK activation, and transcription of immune effector genes.Studies with LAT antibody have demonstrated that LAT is indispensable for T cell development and activation. Knockout models lacking LAT fail to develop mature T cells, and mutations in LAT impair signaling pathways required for adaptive immunity. These findings emphasize its role as a master regulator of immune receptor signaling.Dysregulation of LAT contributes to disease. Research using LAT antibody has revealed that mutations in the LAT gene cause severe combined immunodeficiency, characterized by absent or impaired T cell function. Aberrant LAT signaling has also been implicated in autoimmune disease, where inappropriate activation leads to tissue damage. In oncology, altered LAT expression influences T cell activity within the tumor microenvironment, affecting anti-tumor immunity.LAT antibody is widely used in immunoprecipitation, immunoblotting, and flow cytometry. Immunoprecipitation identifies signaling complexes assembled at LAT, immunoblotting detects phosphorylated and total protein levels, and flow cytometry quantifies expression in T cell populations. These applications make LAT antibody indispensable in immunology research.By supplying validated LAT antibody reagents, NSJ Bioreagents supports studies into T cell receptor signaling, immune development, and pathology. Detection of Linker for activation of T-cells family member 1 provides researchers with insight into how scaffold proteins regulate receptor signaling networks.