Anti-L1/ORF2

Anti-L1/ORF2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
200-901-P11 100 µg - -

6 - 10 business days*

719.00€
 
Anti-L1/ORF2 Antibody is directed against three regions within the endonuclease domain of L1 ORF2... more
Product information "Anti-L1/ORF2"
Anti-L1/ORF2 Antibody is directed against three regions within the endonuclease domain of L1 ORF2 protein.  This product is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above.   Reactivity occurs against mouse L1/ORF2 protein and is useful in determining its presence in various assays.    A BLAST analysis shows reactivity with L1/ORF2 proteins from mouse sources based on 100% homology with the immunizing sequences. Cross reactivity against L1/ORF2 from other sources is unknown. Protein function: Has a reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome. [The UniProt Consortium]
Keywords: Anti-L1, Anti-Pol, Anti-ORF2p, Anti-Gm17492, EC=2.7.7.49, EC=3.1.21.-, Anti-Endonuclease, Anti-Reverse transcriptase, Anti-Long interspersed element-1, Anti-Retrovirus-related Pol polyprotein LINE-1, Anti-LINE-1 retrotransposable element ORF2 protein
Supplier: Rockland Immunochemicals
Supplier-Nr: 200-901-P11

Properties

Application: ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Chicken
Species reactivity: mouse
Immunogen: three synthetic peptides conjugated to keyhole limpet hemocyanin (KLH).  The peptides correspond to regions within the endonuclease domain of L1/ORF2 protein.
Format: Purified

Database Information

UniProt ID : P11369 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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