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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES20681.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES20681.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Potassium channels represent the most complex class of voltage-gated ion channels from both... more
Product information "Anti-KVbeta1"
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alp Protein function: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368, PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6. Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity. Binds NADPH, this is required for efficient down- regulation of potassium channel activity (PubMed:17540341). Has NADPH- dependent aldoketoreductase activity. Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity. [The UniProt Consortium] Recommended dilutions: IHC 1:100-200. Cellular localization: Cytoplasm . Membrane , Peripheral membrane protein , Cytoplasmic side . Cell membrane , Peripheral membrane protein , Cytoplasmic side . Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. .
Keywords: | Anti-KCNA1B, Anti-KCNAB1, Anti-Kv-beta-1, Anti-K(+) channel subunit beta-1, Anti-Voltage-gated potassium channel subunit beta-1, KVbeta1 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES20681 |
Properties
Application: | IHC, IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, mouse |
Immunogen: | Synthetic Peptide of KVbeta1 AA range: 66-116 |
MW: | 50 kD |
Format: | Purified |
Database Information
KEGG ID : | K04882 | Matching products |
UniProt ID : | Q14722 | Matching products |
Gene ID | GeneID 7881 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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