Anti-KSR1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA011215.25	25 µl		-		7 - 10 business days*		369.00€
ATA-HPA011215.100	100 µl		-		7 - 10 business days*		491.00€

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Protein function: Part of a multiprotein signaling complex which promotes phosphorylation of Raf... more

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Product information "Anti-KSR1"

Protein function: Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF, upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 96% and to rat: 95%

Keywords:	Anti-KSR, Anti-KSR1, Anti-Kinase suppressor of Ras 1
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA011215

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: SMIFGVKCKH CRLKCHNKCT KEAPACRISF LPLTRLRRTE SVPSDINNPV DRAAEPHFGT LPKALTKKEH PPAMNHLDSS SNPSSTTSST PSSPAPFPTS SNPSSATTPP NPSPGQRDSR FNFPA (ATA-APrEST71468)