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This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. Protein function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. [The UniProt Consortium]
Keywords:
Anti-K8, Anti-CK-8, Anti-CYK8, Anti-KRT8, Anti-Keratin-8, Anti-Cytokeratin-8, Anti-Type-II keratin Kb8, Anti-Keratin, type II cytoskeletal 8, KRT8 Polyclonal Antibody
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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