Anti-Kindlin-2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A304-577A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A304-577A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or... more

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Product information "Anti-Kindlin-2"

Protein function: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading, this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. [The UniProt Consortium]

Keywords:	Anti-KIND2, Anti-MIG-2, Anti-FERMT2, Anti-Kindlin-2, Anti-Fermitin family homolog 2, Anti-Mitogen-inducible gene 2 protein, Anti-PH domain-containing family C member 1, Anti-Pleckstrin homology domain-containing family C member 1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A304-577A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: sheep, bovine, dog, horse, rabbit, pig, panda, orangutan, rhesus monkey, gorilla, chimpanzee, cetartiodactyla, white-tufted-ear marmoset, vampire bat, cat, crab-eating macaque, gray short-tailed opossum, chinese tree shrew)
Immunogen:	synthetic peptide. The epitope recognized by A304-577A-T maps to a region between residue 175 to 225 of human Kindlin-2 using the numbering given in entry NP_006823.1 (GeneID 10979).
Format:	Antigen Affinity Purified