Anti-Ki-67 / Marker of proliferation Ki-67, clone MSVA-267M

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Ki-67 antigen (MKI67) is a nuclear proliferation-associated protein encoded by the MKI67 gene and is widely used as a marker of actively cycling cells in normal and neoplastic tissues. Ki-67 Antibody for IHC / Ki-67 IHC Antibody is developed for immunohistochemistry detection of this well-established proliferation marker in formalin-fixed, paraffin-embedded tissue sections. Because Ki-67 expression is closely linked to cell cycle activity and is largely absent in quiescent cells, immunohistochemistry staining provides a practical way to visualize proliferative compartments directly within preserved tissue architecture.Ki-67 antibody, also referred to as Ki67 antibody, MKI67 antibody, or Antigen KI-67 antibody in the literature, detects a protein that localizes predominantly to the nucleus during active phases of the cell cycle. In immunohistochemistry studies, Ki-67 staining typically appears as brown nuclear chromogenic signal in proliferating cells, allowing clear distinction between cycling and non-cycling populations. This makes Ki-67 Antibody for IHC especially useful for assessing germinal centers, basal proliferative zones, intestinal crypt compartments, and tumor cell populations with increased growth fraction.The value of immunohistochemistry for Ki-67 lies in its ability to combine proliferation assessment with tissue morphology. In normal tissues, nuclear Ki-67 staining is usually confined to expected proliferative compartments, while differentiated or resting cells show little to no signal. In tumors, Ki-67 IHC antibody staining often highlights variable fractions of proliferating malignant nuclei, helping researchers examine growth patterns across carcinomas, lymphomas, sarcomas, and other neoplasms. The intensity and distribution of nuclear staining can therefore provide useful visual context when comparing different tumor areas or tissue types in research settings.Ki-67 is expressed during G1, S, G2, and mitotic phases, but is generally not detected in resting G0 cells. At the subcellular level, the protein associates with the nucleus and shows characteristic changes in distribution during mitosis. This biology explains why immunohistochemistry staining with Ki-67 antibodies is widely used to identify proliferative activity rather than lineage alone. In FFPE sections, the expected finding is selective nuclear labeling rather than cytoplasmic or membranous signal, which helps support straightforward microscopic interpretation.Ki-67 Antibody for IHC / Ki-67 IHC Antibody provides a valuable tool for immunohistochemistry-based evaluation of proliferating cells in both normal and cancer tissues. By highlighting nuclear expression of Ki-67 / MKI67 within intact histologic context, this antibody supports studies of tumor biology, tissue turnover, growth fraction, and cellular proliferation in pathology-oriented research.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.