Anti-Ki-67, clone YN00996m

Ki-67 antigen is a nuclear protein related to cell proliferation, which may be the key factor of cell proliferation. In addition, Ki-67 is related to ribosomal RNA transcription. Ki-67 is present in G1, S, M and G2 phases of cell division cycle, but not in G0 phase of cell quiescence. Ki-67 is used to judge the different types of tumors, because it exists in all proliferating cells (normal cells and tumor cells), and it is a very good marker to determine the proliferation rate of a given cell population. Protein function: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes. May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). [The UniProt Consortium]