Anti-Kdm6b

Enables beta-catenin binding activity, histone H3-tri/di-methyl-lysine-27 demethylase activity, and sequence-specific DNA binding activity. Involved in several processes, including histone H3-K27 demethylation, mesodermal cell differentiation, and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular response to hydrogen peroxide, histone demethylation, and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain, gut, liver, metanephros, and olfactory epithelium. Orthologous to human KDM6B (lysine demethylase 6B). Protein function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T- box factors and the SMARCA4-containing SWI/SNF remodeling complex (PubMed:21095589). [The UniProt Consortium]