Anti-KDM6A

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA002111.25	25 µl		-		7 - 10 business days*		320.00€
ATA-HPA002111.100	100 µl		-		7 - 10 business days*		450.00€

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Protein function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3,... more

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Product information "Anti-KDM6A"

Protein function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 95% and to rat: 94%

Keywords:	Anti-UTX, Anti-KDM6A, Anti-Histone demethylase UTX, Anti-Lysine-specific demethylase 6A, Anti-[histone H3]-trimethyl-L-lysine(27) demethylase 6A, Anti-Ubiquitously-transcribed TPR protein on the X chromosome
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA002111

Properties

Application:	WB, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: IGNNHITGSG SNGNVPYLQR NALTLPHNRT NLTSSAEEPW KNQLSNSTQG LHKGQSSHSA GPNGERPLSS TGPSQHLQAA GSGIQNQNGH PTLPSNSVTQ GAALNHLSSH TATSGGQQGI TLTKESKPSG NILTVPETSR HT (ATA-APrEST85171)