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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG40757.100 | 100 µl | - | - |
6 - 14 business days* |
624.00€
|
Protein function: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3,... more
Product information "Anti-KDM3A"
Protein function: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. [The UniProt Consortium]
Keywords: | Anti-KDM3A, Anti-JHDM2A, EC=1.14.11.-, Anti-Lysine-specific demethylase 3A, Anti-Jumonji domain-containing protein 1A, Anti-JmjC domain-containing histone demethylation protein 2A |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG40757 |
Properties
Application: | IHC (paraffin), WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Synthetic peptide within aa. 350-450 of Human KDM3A (NP_060903.2) |
MW: | 147 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K15601 | Matching products |
UniProt ID : | Q9Y4C1 | Matching products |
Gene ID | GeneID 55818 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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