Anti-KCTD6

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA036100.100	100 µl		-		7 - 10 business days*		491.00€

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Protein function: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3... more

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Product information "Anti-KCTD6"

Protein function: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1, the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1, the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 99% and to rat: 100%

Keywords:	Anti-KCTD6, Anti-KCASH3 protein, Anti-BTB/POZ domain-containing protein KCTD6, Anti-Potassium channel tetramerization domain-containing protein 6
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA036100

Properties

Application:	IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: QIEPLIQCLN DPKPLYPMDT FEEVVELSST RKLSKYSNPV AVIITQLTIT TKVHSLLEGI SNYFTKWNKH M (ATA-APrEST79479)