Anti-KCNQ1, clone S37A-10

Anti-KCNQ1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with KCNQ1 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with KCNQ1 from other sources has not been determined. Channels and Transporters research. Protein function: Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. [The UniProt Consortium]