Anti-KARS / LysRS

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG40056.100	100 µl		-	-	10 - 15 business days*		707.00€

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Protein function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2... more

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Product information "Anti-KARS / LysRS"

Protein function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739). [The UniProt Consortium]

Keywords:	Anti-KARS, Anti-LysRS, Anti-KIAA0070, Anti-Lysine--tRNA ligase, Anti-Lysyl-tRNA synthetase
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG40056

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant fusion protein corresponding to aa. 298-597 of Human KARS (NP_005539.1)
MW:	71 kD
Format:	Affinity Purified