Anti-JPO2 (CDCA7L, RAM2, Cell Division Cycle-associated 7-like Protein, Protein JPO2, Transcription

Cell division cycle-associated 7-like protein (or RAM2) is a transcription factor which plays a role in transcriptional regulation and apoptotic signaling pathways. It acts as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to promoter. It also plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. It may act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 2-5ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: HCT-116 (human) and NIH 3T3 (mouse) cell lysate, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.