Anti-JMJD1A/JHDM2A

Anti-JMJD1A/JHDM2A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-538A-T 10 µl (10 µg) -

3 - 9 business days

125.00€
A301-538A 100 µl (100 µg) -

3 - 9 business days

430.00€
 
Protein function: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3,... more
Product information "Anti-JMJD1A/JHDM2A"
Protein function: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. [The UniProt Consortium]
Keywords: Anti-KDM3A, Anti-JHDM2A, EC=1.14.11.-, Anti-Lysine-specific demethylase 3A, Anti-Jumonji domain-containing protein 1A, Anti-JmjC domain-containing histone demethylation protein 2A
Supplier: Bethyl Laboratories
Supplier-Nr: A301-538A-T

Properties

Application: IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Bovine, Dog, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, European Domestic Ferret, Small-eared Galago, Thirteen-lined Ground Squirrel, Little Brown Bat, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-538A-T maps to a region between residue 1025 and 1075 of human jumonji domain containing 1A (JmjC domain-containing histone demethylation protein 2A) using the numbering given in entry NP_060903.2 (GeneID 55818).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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