Anti-JIK/TAOK3

Jun kinase-inhibitory kinase (JIK) is a member of the STE20 serine/threonine kinase family that has been demonstrated to negatively regulate c-jun N-terminal kinase. When overexpressed, JIK has been demonstrated to activate the ERK1/ERK2 (extracellular signal-regulated kinase) pathway. Protein function: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). [The UniProt Consortium]