Anti-JAM1 (human), Rabbit Monoclonal (RM275)

Recombinant Antibody. This antibody reacts to human JAM1 (Junctional adhesion molecule 1). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. JAM-1 (CD321, F11R, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. JAM-1 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. JAM-1 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. JAM-1 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. JAM-1 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion and metastasis.