Anti-JAGN1

Protein function: Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport, it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway, possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. [The UniProt Consortium] Recommended dilutions: WB 1:1000-2000. Cellular localization: Endoplasmic reticulum membrane , Multi-pass membrane protein .