Anti-ITGB6

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA023626.25	25 µl		-		7 - 10 business days*		330.00€
ATA-HPA023626.100	100 µl		-		7 - 10 business days*		463.00€

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Protein function: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and... more

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Product information "Anti-ITGB6"

Protein function: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G- D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 90% and to rat: 88%

Keywords:	Anti-ITGB6, Anti-Integrin beta-6
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA023626

Properties

Application:	ICC, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: RGDCVCGKCV CTNPGASGPT CERCPTCGDP CNSKRSCIEC HLSAAGQARE ECVDKCKLAG ATISEEEDFS KDGSVSCSLQ GENECLITFL ITTDNEGKTI IHSI (ATA-APrEST70079)