Anti-ITGA5

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA002642.25	25 µl		-		7 - 10 business days*		240.00€
ATA-HPA002642.100	100 µl		-		7 - 10 business days*		358.00€

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Protein function: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and... more

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Product information "Anti-ITGA5"

Protein function: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 85% and to rat: 82%

Keywords:	Anti-FNRA
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA002642

Properties

Application:	IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: DQPQKEEDLG PAVHHVYELI NQGPSSISQG VLELSCPQAL EGQQLLYVTR VTGLNCTTNH PINPKGLELD PEGSLHHQQK REAPSRSSAS SGPQILKCPE AECFRLRCEL GPLHQQESQS LQLHFRVWA (ATA-APrEST86565)