Anti-ITGA4/CD49D/Integrin alpha-4

Anti-ITGA4/CD49D/Integrin alpha-4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A305-255A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A305-255A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for... more
Product information "Anti-ITGA4/CD49D/Integrin alpha-4"
Protein function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). [The UniProt Consortium]
Keywords: Anti-ITGA4, Anti-CD49D, Anti-CD49d, Anti-Integrin alpha-4, Anti-Integrin alpha-IV, Anti-VLA-4 subunit alpha, Anti-CD49 antigen-like family member D
Supplier: Bethyl Laboratories
Supplier-Nr: A305-255A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A305-255A-T maps to a region between residue 982 to 1032 of human Integrin alpha-4 using the numbering given in entry P13612.3 (GeneID 3676).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-ITGA4/CD49D/Integrin alpha-4"
Write a review
or to review a product.
Viewed