Anti-ITGA2B/CD41 Chimeric Monoclonal Antibody (Clone 7E3 (Abciximab))

CD41, also known as integrin alpha2b (ITGA2B), is a protein subunit of the heterodimeric integrin alphaIIbbeta3 complex. It is composed of N-terminal extracellular beta-propeller, thigh, calf-1, and calf-2 domains, a transmembrane domain, and a C-terminal cytoplasmic domain. CD41 is expressed in platelets, as well as fetal hematopoietic stem and progenitor cells and a subtype of aging adult hematopoietic stem cells. Signaling through the alphaIIbbeta3 complex occurs via inside-out or outside-in mechanisms. Inside-out signaling occurs when a ligand binds and increases the affinity and avidity of the complex for ligands containing the Arg-Gly-Asp integrin recognition sequence, such as fibrinogen and von Willebrand factor, that are required for platelet aggregation and adhesion. Outside-in signaling of the alphaIIbbeta3 complex regulates platelet spreading and plug formation and occurs due to integrin clustering or ligation and integration signaling from additional plasma membrane receptors. Various mutations in ITGA2B or ITGB3, the gene encoding CD61, the alphaIIbbeta3 complex beta3 subunit, lead to a loss of alphaIIbbeta3 expression and are associated with Glanzmann thrombasthenia, a coagulation disorder characterized by impaired clotting, abnormal bleeding, and bruising. Cayman's ITGA2B/CD41 Chimeric Monoclonal Antibody (Clone 7E3 (Abciximab)) was produced recombinantly from the original 7E3 Fab antibody sequence and can be used for flow cytometry (FC). The 7E3 antibody was generated by immunization of mice with washed platelets, followed by fusion of the mouse spleen cells with a mouse myeloma cell line and subcloning.Synonyms: GP2B, GPIIb, Integrin alpha2b, Integrin alphaIIb, ITGA2B, Platelet Fibrinogen Receptor, Platelet Glycoprotein IIb of IIB/IIIa Complex. Immunogen: Human CD41. Clone Designation: 7E3 (Abciximab). Formulation: (Request formulation change), 200 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 0.02% ProClin(TM) 300. Host: Chimeric Monoclonal Antibody. Isotype: IgG1kappa. Applications: FC, block. Cross Reactivity: ( (+)) CD41. UniProt Accession #: P08514.