Anti-IRF8

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG40926.50	50 µg		-	-	6 - 14 business days*		551.00€

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Protein function: Plays a role as a transcriptional activator or repressor (PubMed:25122610).... more

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Product information "Anti-IRF8"

Protein function: Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Positively regulates macroautophagy in dendritic cells (PubMed:29434592). [The UniProt Consortium]

Keywords:	Anti-IRF8, Anti-ICSBP, Anti-IRF-8, Anti-ICSBP1, Anti-H-ICSBP, Anti-Interferon regulatory factor 8, Anti-Interferon consensus sequence-binding protein
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG40926

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, rat (Expected: mouse, bovine)
Immunogen:	Synthetic peptide corresponding to aa. 411-426 of Human IRF8. (ASHQRSFFRENQQITV)
MW:	48 kD
Format:	Antigen Affinity Purified