Anti-IRF4/MUM1 (C-Term) Rabbit Monoclonal Antibody (Clone RM352)

Interferon regulatory factor 4 (IRF4), also known as multiple myeloma oncogene 1 (MUM1), is a transcription factor and member of the IRF family with roles in lymphocyte activation and the generation of immunoglobulin-secreting (Ig-secreting) plasma cells. It is composed of an N-terminal DNA binding domain, a linker domain, an interferon activation domain, and a C-terminal autoinhibitory region. IRF4 is primarily expressed in plasma cells and activated T cells but is also expressed in the heart, kidney, liver, and brain. Unlike other IRF transcription factors, IRF4 is not IFN-responsive and is activated by induction of the NF-kappaB pathway by various activators of lymphocyte activation and differentiation, such as LPS, concanavalin A (Cay-14951), bacterial toxins, IL-4, and antigen receptor engagement. Irf4-/- mice lack Ig-secreting plasma cells, as well as exhibit defective T helper cell differentiation and decreased survival in a model of bacterial CpG-induced septic shock. IRF4 expression is associated with poor prognosis in patients with B cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL). Cayman's IRF4/MUM1 (C-Term) Rabbit Monoclonal Antibody (Clone RM352) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: Interferon Regulatory Factor 4, LSIRF, Lymphocyte-specific Interferon Regulatory Factor, Multiple Myeloma Oncogene 1. Immunogen: Peptide from the C-terminal region of human IRF4. Clone Designation: RM352. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) IRF4.