Anti-IRF4 / Interferon regulatory factor 4 (recombinant antibody), clone RM352

Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. This antibody reacts to human MUM1/IRF4 (Interferon regulatory factor 4). Protein function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA- 3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. [The UniProt Consortium]