Anti-IRAK3 (IRAK-M, IRAKM, IRAK-3, IL-1 receptor-associated kinase 3)

Interleukin-1 receptor-associated kinase 3, also called IRAK3 or IRAKM is an enzyme that in humans is encoded by the IRAK3 gene. The IRAKM gene consists of 12 exons spanning a region of approximately 60 kb in chromosome 12q14.3. This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. UniProt Number: Q9Y616, Gene ID: IRAK3, Applications: Suitable for use in Western Blot. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.