Anti-IRAK1

Anti-IRAK1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-744A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-744A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-744A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Serine/threonine-protein kinase that plays a critical role in initiating innate... more
Product information "Anti-IRAK1"
Protein function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. [The UniProt Consortium]
Keywords: Anti-IRAK, Anti-IRAK1, Anti-IRAK-1, EC=2.7.11.1, Anti-Interleukin-1 receptor-associated kinase 1
Supplier: Bethyl Laboratories
Supplier-Nr: A303-744A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Sooty Mangabey, Crab-eating Macaque, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-744A-T maps to a region between residue 662 and 712 of human Interleukin-1 Receptor-Associated Kinase 1 using the numbering given in entry NP_001560.2 (GeneID 3654).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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