Anti-IRAK-1

Nuclear factor-kappaB (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF-alpha, and LPS. A serine/threonine protein kinase associated with interleukin-1 receptor-associated kinase 1 (IRAK-1) and its homologue murine pelle-like protein kinase (mPLK) has been identified. IRAK-1 is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK-1 mediates a signaling cascade leading to NF-kappaB activation by members of the IL-1 family including IL-1 and IL-18 (also known as IGIF).Synonyms: Interleukin-1 Receptor-Associated Kinase 1. Immunogen: synthetic peptide corresponding to human IRAK-1 amino acids 700-712. Amino Acids: amino acids 700-712. Formulation: (Request formulation change), 100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Host: Rabbit. Applications: IP and WB. Cross Reactivity: (-) IRAK-2.