Anti-IPMK (PACO00979)

Anti-IPMK (PACO00979)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-PACO00979.50 50 µg - -

9 - 20 business days*

320.00€
 
IPMK Antibody from Assay Genie with reactivity against Human, Mouse, Rat, Monkey and for use in... more
Product information "Anti-IPMK (PACO00979)"
IPMK Antibody from Assay Genie with reactivity against Human, Mouse, Rat, Monkey and for use in ELISA, WB, IHC applications. IPMK Antibody is Polyclonal and is a IgG isotype antibody from Assay Genie.. Protein function: Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5- trisphosphate (PubMed:30420721, PubMed:28882892). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho- MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6). [The UniProt Consortium]
Keywords: Anti-IPMK, Anti-Inositol polyphosphate multikinase, Anti-Inositol 1,3,4,6-tetrakisphosphate 5-kinase
Supplier: Assay Genie
Supplier-Nr: PACO00979

Properties

Application: ELISA, WB, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat, monkey
Immunogen: synthesized peptide derived from the C-terminal region of human IPMK.
Formula: affinity purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-IPMK (PACO00979)"
Write a review
or to review a product.
Viewed