Anti-Interleukin-8 (IL-8) (dolphin)

The Dolphin IL-8 (CXCL8) polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Dolphin IL-8 ELISA. The Dolphin IL-8 polyclonal antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IL-8 - Weak) (Canine IL-8 - Weak) (Dolphin IL-8 - Strong) (Equine IL-8 - Weak) (Feline IL-8 - Weak) (Guinea Pig IL-8 - None) (Human IL-8 - None) (Rabbit IL-8 - None) (Swine IL-8 - Weak). For research use only. Made in the USA Protein function: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways. [The UniProt Consortium]