Anti-Interleukin-6Ralpha/CD126 Rabbit Monoclonal Antibody (Clone 033)

Interleukin-6Ralpha (IL-6Ralpha), also known as CD126, is a type I cytokine receptor. It is composed of an immunoglobulin-like domain, a cytokine-binding domain, a transmembrane domain, and a cytoplasmic domain and forms a heteromeric complex with IL-6 and gp130, which is the signal transducing subunit of the IL-6R that primarily acts through the JAK/STAT3 pathway. IL-6Ralpha is expressed in hepatocytes and monocytes and is localized to the plasma membrane but also exists as a soluble form (sIL-6Ralpha) that is primarily generated via proteolytic cleavage of membrane-bound IL-6Ralpha, but can also be formed via alternative splicing. Binding of IL-6 to membrane-bound IL-6Ralpha, known as classical signaling, upregulates the synthesis of acute phase proteins, induces lipolysis in the liver, and induces the differentiation of T and B cells and is primarily anti-inflammatory. Trans-signaling consists of IL-6 binding to sIL-6R, which has various pro-inflammatory effects. Knockdown of IL6R increases sensitivity to tamoxifen in breast cancer cells. Formulations containing chimeric anti-IL-6Ralpha monoclonal antibodies have been used in the treatment of rheumatoid arthritis, idiopathic arthritis, giant cell arteritis, cytokine release syndrome, and COVID-19. Cayman's Interleukin-6Ralpha/CD126 Rabbit Monoclonal Antibody (Clone 033) can be used for ELISA (capture) and flow cytometry (FC) applications.Synonyms: IL-6Ralpha, Interleukin-6 Receptor Subunit alpha. Immunogen: Recombinant mouse IL-6Ralpha. Clone Designation: 033. Formulation: (Request formulation change), 50, 100 µl, or 1 ml of protein A-affinity purified monoclonal antibody. Storage Buffer: 0.2 µm filtered solution in PBS. Host: Rabbit. Isotype: IgG. Applications: ELISA (capture), FC. Cross Reactivity: (+) IL-6Ralpha, (+) sIL-6Ralpha.