Anti-Interferon gamma / IFNG, clone IFNG/466

0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 20-25kDa, identified as human interferon. This MAb is specific to human IFNg and recognizes both recombinant and native human IFN-gamma. T lymphocytes and NK cells mainly produce IFNg. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses, including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak anti-viral and anti-proliferative activity, and potentiates the antiviral and anti-tumor effects of IFN-a/b (type I interferon). Protein function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. [The UniProt Consortium]