Anti-Interferon gamma

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Interferon gamma is an inflammatory cytokine that has been implicated in the development of fibrosis in inflamed tissues. The production of IFNg, which is under genetic control, can influence the development of fibrosis in lung allografts. It is also produced by natural killer(NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Interferon gamma is believed to be crucial for host defence against many infections. Genetically determined variability in IFNg and expression might be important for the development of tuberculosis. It activates human macrophage oxidative metabolism and antimicrobial activity. In addition to having antiviral activity, Interferon gamma has important immunoregulatory functions and plays an important role in the control of neointima proliferation. Protein function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. [The UniProt Consortium]