Anti-Interferon gamma (IFNG), clone G-23

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 20-25kDa, identified as human interferon. This mAb is specific to human IFN- and recognizes both recombinant and native human IFN-gamma,. It does not neutralize the activity of IFN-. T lymphocytes and NK cells mainly produce IFN-. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses, including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak anti-viral and anti-proliferative activity, and potentiates the antiviral and anti-tumor effects of IFN- (type I interferon). Protein function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. [The UniProt Consortium]