Anti-Integrin alpha 4 / ITGA4, clone RM268 (recombinant antibody)

Anti-Integrin alpha 4 / ITGA4, clone RM268 (recombinant antibody)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R20285-0.1ML 100 µl - -

3 - 10 business days*

737.00€
 
Antibody in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This recombinant ITGA4 antibody... more
Product information "Anti-Integrin alpha 4 / ITGA4, clone RM268 (recombinant antibody)"
Antibody in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This recombinant ITGA4 antibody reacts to the cytoplasmic domain of human Integrin alpha 4. Protein function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). [The UniProt Consortium]
Keywords: Anti-ITGA4, Anti-CD49d, Anti-CD49D, Anti-Integrin alpha-4, Anti-Integrin alpha-IV, Anti-VLA-4 subunit alpha, Anti-CD49 antigen-like family member D, Recombinant Integrin alpha 4 Antibody / ITGA4
Supplier: NSJ Bioreagents
Supplier-Nr: R20285

Properties

Application: WB, IHC
Antibody Type: Monoclonal
Clone: RM268
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A peptide corresponding to the C-terminus of human Integrin alpha 4 was used as the immunogen for this recombinant ITGA4 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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