Anti-INSM2 / Insulinoma-associated protein 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. INSM2 antibody detects Insulinoma-associated protein 2, a zinc finger transcriptional regulator implicated in neuroendocrine differentiation, metabolic regulation, and pancreatic development. The UniProt recommended name is Insulinoma-associated protein 2 (INSM2). This nuclear protein belongs to the INSM family of transcriptional repressors, which also includes INSM1, and contributes to neuronal and endocrine lineage specification through transcriptional control of differentiation-related genes.Functionally, INSM2 antibody identifies a 566-amino-acid nuclear protein characterized by two C2H2-type zinc finger domains responsible for DNA binding. INSM2 functions primarily as a transcriptional repressor by interacting with chromatin modifiers such as histone deacetylases (HDACs) and corepressors, leading to silencing of target genes involved in progenitor proliferation and differentiation timing. Its expression is enriched in neuroendocrine tissues, including pancreatic islets, hypothalamus, and pituitary gland.The INSM2 gene is located on chromosome 14q32.33 and is transcriptionally regulated by developmental factors that control endocrine and neural specification. During embryogenesis, INSM2 expression marks neuroendocrine progenitors, where it modulates hormone biosynthesis and secretory machinery gene networks. In pancreatic beta cells, INSM2 contributes to insulin production and glucose homeostasis by regulating transcription of genes linked to secretion and vesicle trafficking.In the central nervous system, INSM2 plays roles in hypothalamic and pituitary differentiation, influencing neuroendocrine circuit formation. Its function overlaps with, but is distinct from, INSM1, with both cooperating to maintain endocrine identity and suppress premature differentiation. In metabolic tissues, INSM2 has been implicated in lipid and glucose metabolism, linking endocrine signaling to energy balance. Emerging studies also associate INSM2 with neuroendocrine tumors, where its upregulation may reflect differentiation status and secretory activity.INSM2 antibody is widely used in developmental biology, endocrinology, and neurobiology research. It is suitable for western blotting, immunohistochemistry, and immunofluorescence to detect INSM2 expression in neural and endocrine tissues. This antibody supports studies of transcriptional regulation, endocrine cell differentiation, and metabolic gene networks. In translational research, INSM2 serves as a marker for neuroendocrine lineage commitment and tumor differentiation.Structurally, INSM2 contains zinc finger DNA-binding motifs and nuclear localization signals that enable chromatin association. It functions within transcriptional repressor complexes containing HDAC1/2 and REST corepressors. NSJ Bioreagents provides INSM2 antibody reagents validated for use in transcriptional regulation, neuroendocrine development, and metabolic research.