Anti-INHA / Inhibin subunit alpha, clone MSVA-561R

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Inhibin subunit alpha (INHA) is a secreted glycoprotein hormone component encoded by the INHA gene and produced primarily by granulosa cells of the ovary and Sertoli cells of the testis. The protein is widely known as Inhibin alpha and forms part of the heterodimeric hormones inhibin A and inhibin B within the transforming growth factor beta signaling family. INHA Antibody for IHC (clone MSVA-561R) recognizes the inhibin alpha protein and is intended for immunohistochemistry based studies examining INHA expression patterns in normal endocrine tissues and in tumors derived from steroidogenic cell lineages.Immunohistochemistry detection of INHA is widely used in pathology and research settings to identify steroid producing and sex cord related cell populations in tissue sections. In formalin-fixed, paraffin-embedded tissues, inhibin alpha is typically observed as cytoplasmic staining in endocrine cells involved in reproductive hormone production. In normal tissues, strong immunohistochemistry signal is commonly detected in ovarian granulosa cells, luteinized stromal cells, adrenal cortical cells, and Sertoli cells within seminiferous tubules of the testis. These characteristic staining patterns make INHA an established marker for identifying steroidogenic cell types in tissue sections.Because of its restricted cellular distribution, inhibin alpha immunohistochemistry is frequently used in research evaluating endocrine and sex cord stromal tumors. Positive cytoplasmic staining can be observed in ovarian granulosa cell tumors, sex cord stromal tumors of the testis, and adrenal cortical neoplasms. In contrast, most epithelial carcinomas and non endocrine tissues show minimal or no detectable staining, allowing INHA immunohistochemistry to help distinguish steroidogenic tumors from other malignancies in tissue based studies.Large scale immunohistochemistry analysis of normal tissue microarrays further demonstrates the selective distribution of INHA expression. Strong staining is typically observed in adrenal cortex, ovarian corpus luteum, and testicular Sertoli cells, while the majority of epithelial organs and connective tissues remain negative. This restricted staining profile highlights the value of INHA as a marker for endocrine differentiation in histological specimens.INHA Antibody for IHC (clone MSVA-561R) provides a recombinant rabbit monoclonal reagent designed for consistent immunohistochemistry detection of inhibin alpha in formalin-fixed, paraffin-embedded tissue sections. Detection typically appears as cytoplasmic HRP-DAB signal in steroidogenic or sex cord related cells, supporting studies of endocrine tissue biology, tumor classification, and steroid producing cell lineages in tissue based analysis.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.