Anti-IMMP2L / Inner mitochondrial membrane peptidase subunit 2-like

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. IMMP2L antibody detects Inner mitochondrial membrane peptidase subunit 2-like protein, encoded by the IMMP2L gene on chromosome 7q31.1. IMMP2L antibody is used to study this mitochondrial peptidase that processes signal peptides from proteins targeted to the inner mitochondrial membrane. IMMP2L belongs to the peptidase M76 family and is essential for mitochondrial protein maturation, respiratory function, and cellular energy metabolism. Expression is broadly detected across tissues, with high levels in heart, skeletal muscle, and brain where oxidative phosphorylation demand is highest.Structurally, IMMP2L is a membrane-bound subunit of the inner mitochondrial membrane peptidase (IMP) complex. This complex removes targeting peptides from proteins after import into mitochondria, enabling their proper integration or function within the inner membrane. IMMP2L, along with its partner IMMP1L, provides catalytic activity within this protease system. It is characterized by conserved zinc-binding motifs and transmembrane helices that localize it to the inner membrane.Functionally, IMMP2L processes mitochondrial proteins such as cytochrome c1 and subunits of cytochrome oxidase, enabling their maturation and assembly into respiratory complexes. By regulating processing of nuclear-encoded mitochondrial proteins, IMMP2L ensures proper electron transport chain activity and ATP production. Deficiency leads to accumulation of precursor proteins, impaired respiration, and increased oxidative stress. Knockdown or mutation of IMMP2L disrupts mitochondrial function, highlighting its essential role. Researchers use IMMP2L antibody to explore mitochondrial protein processing, respiratory chain assembly, and energy metabolism.Clinically, IMMP2L has been implicated in neurological and psychiatric conditions. Genetic variants and structural rearrangements involving IMMP2L are associated with Tourette syndrome, autism spectrum disorders, and attention-deficit hyperactivity disorder. While the exact pathogenic mechanism remains unclear, disruption of mitochondrial protein processing is thought to alter neuronal metabolism and signaling. IMMP2L variants have also been linked to Parkinson's disease and age-related mitochondrial decline. These findings make IMMP2L a target of interest in neurodevelopmental and neurodegenerative research. NSJ Bioreagents provides IMMP2L antibody as a high-quality reagent to study mitochondrial proteostasis, neurological disease, and energy homeostasis.Experimentally, IMMP2L antibody is applied in western blotting to detect the ~90 kDa protein, in immunofluorescence to study mitochondrial localization, and in immunohistochemistry to evaluate tissue-specific expression. Immunoprecipitation with IMMP2L antibody can isolate the IMP complex, enabling analysis of its substrates and activity. These approaches provide tools to dissect mitochondrial protein processing pathways in health and disease.