Anti-IL-6 (canine)

The Canine IL-6 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Canine IL-6 ELISA. The Canine IL-6 antibody was produced in rabbits and is antigen-affinity purified. This antibody has shown minimal or no cross-reactivity with atlantic salmon, bat, bovine, caprine, chicken, cynomolgus monkey, dolphin, equine, feline, ferret, guinea pig, human, mouse, ovine, rabbit, rat, swine, or zebrafish IL-6 proteins. For research use only. Made in the USA. Protein function: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane- bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. [The UniProt Consortium]