Anti-IL-3

Anti-IL-3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AN006080L.25 25 µl - -

7 - 16 business days*

109.00€
E-AN006080L.100 100 µl - -

7 - 16 business days*

316.00€
 
IL3 (Interleukin 3) is a Protein Coding gene. Diseases associated with IL3 include Hematologic... more
Product information "Anti-IL-3"
IL3 (Interleukin 3) is a Protein Coding gene. Diseases associated with IL3 include Hematologic Cancer and Allergic Disease. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation. Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK. Protein function: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage- restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (PubMed:10376805, PubMed:31990690, PubMed:8378315). Alternatively, contributes to cell survival under oxidative stress in non- hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK. [The UniProt Consortium]
Keywords: Anti-Il3, Anti-IL-3, Anti-MCGF, Anti-Csfmu, Anti-Interleukin-3, Anti-Mast cell growth factor, Anti-P-cell-stimulating factor, Anti-Hematopoietic growth factor, Anti-Multipotential colony-stimulating factor, IL-3 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AN006080L

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant Mouse IL-3 protein expressed by E.coli

Handling & Safety

Storage: -20°C (protect from light)
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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