Anti-IL-18Ra (human), Azide Free Clone B-E43 [Mouse]

Specificity: Recognises the IL-18Ra, a 63 kDa protein, Format: Phosphate-buffered saline. Sterile-filtered through 0.22 µm and treated to remove endotoxins. Carrier and preservative free, Storage: Store at +2-8°C for 12 months. For longer storage, freeze aliquots, Application Notes: Blocks human IFNg secretion induced by IL-18 stimulated cells Protein function: Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3. [The UniProt Consortium]