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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R31705 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. NF-kappa-B inhibitor beta, also known as... more
Product information "Anti-IkB beta"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. NF-kappa-B inhibitor beta, also known as IKBB or TRIP9, is a protein that in humans is encoded by the NFKBIB gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with it and therebye trapping it in the cytoplasm. It has been found that in vivo, IkB beta serves both to inhibit and to facilitate the inflammatory response. Its degradation releases NF-kappa-B dimers, which upregulate proinflammatory target genes such as TNF-alpha. Surprisingly, absence of IkB beta results in a dramatic reduction of TNF-alpha in response to lipopolysaccharide, even though activation of NF-kappa-B is normal. Protein function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. [The UniProt Consortium]
Keywords: | Anti-IKBB, Anti-IkB-B, Anti-TRIP-9, Anti-NFKBIB, Anti-IkB-beta, Anti-IkappaBbeta, Anti-NF-kappa-BIB, Anti-I-kappa-B-beta, Anti-TR-interacting protein 9, Anti-NF-kappa-B inhibitor beta, Anti-Thyroid receptor-interacting protein 9, IkB beta Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R31705 |
Properties
Application: | WB, IHC (paraffin) |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Human partial recombinant protein (AA 56-237) was used as the immunogen for this IkB beta antibody. |
Format: | Purified |
Database Information
KEGG ID : | K02581 | Matching products |
UniProt ID : | Q15653 | Matching products |
Gene ID | GeneID 4793 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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