Anti-Ikaros

Anti-Ikaros
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-516A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-516A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-516A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Transcription regulator of hematopoietic cell differentiation... more
Product information "Anti-Ikaros"
Protein function: Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta- globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). [The UniProt Consortium]
Keywords: Anti-IK1, Anti-IKZF1, Anti-DNA-binding protein Ikaros, Anti-Lymphoid transcription factor LyF-1, Anti-Ikaros family zinc finger protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: A303-516A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Primates, Cotton-top Tamarin, Bornean Orangutan, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-516A-T maps to a region between residue 375 and 425 of human IKAROS family zinc finger 1 using the numbering given in entry NP_006051.1 (GeneID 10320).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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