Anti-IGSF11 / Immunoglobulin superfamily member 11

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. IGSF11 antibody detects Immunoglobulin superfamily member 11, encoded by the IGSF11 gene on chromosome 3q13.33. IGSF11 antibody is commonly used in neuroscience, immunology, and cancer biology. IGSF11 is a cell adhesion molecule belonging to the immunoglobulin superfamily, characterized by extracellular Ig-like domains, a single transmembrane helix, and a short cytoplasmic tail. It is primarily expressed in brain and testis, with roles in synapse formation, neuronal communication, and cell adhesion in the reproductive system.Structurally, IGSF11 is a ~55 kDa protein containing two extracellular Ig-like domains that mediate homophilic and heterophilic interactions. These domains enable IGSF11 to participate in cell-cell adhesion, particularly in neurons and germ cells. Alternative splicing generates isoforms with differences in extracellular and cytoplasmic domains, which may influence adhesion properties.Functionally, IGSF11 contributes to excitatory synapse development in the brain. It interacts with postsynaptic scaffolding proteins, influencing AMPA receptor trafficking and synaptic plasticity. In testes, IGSF11 is expressed in Sertoli cells and germ cells, where it supports spermatogenesis by mediating cell adhesion. Researchers use IGSF11 antibody to study synapse biology, reproductive function, and immune cell adhesion.Clinically, IGSF11 has been linked to neurological disorders, including autism spectrum disorders, due to its role in synaptic communication. It has also been implicated in cancer, where altered expression influences tumor progression and immune evasion. Because of its testis-enriched expression, IGSF11 has been considered a cancer-testis antigen with potential as an immunotherapy target. NSJ Bioreagents provides IGSF11 antibody for studies in neuroscience, fertility, and oncology.Experimentally, IGSF11 antibody is applied in western blotting to detect the ~55 kDa protein, in immunohistochemistry to analyze expression in brain and testis, and in immunofluorescence microscopy to study synaptic localization. Co-immunoprecipitation with IGSF11 antibody helps identify interacting partners in synaptic complexes and adhesion pathways.