Anti-IGFL3 / IGF-like family member 3

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. IGFL3 antibody detects IGF-like family member 3, encoded by the IGFL3 gene on chromosome 19q13.32. IGFL3 antibody is commonly used in research on growth factor biology, signaling, and development. IGFL3 belongs to the IGF-like family of secreted proteins, which share structural features with insulin-like growth factors but often have distinct biological activities. IGFL3 is expressed primarily in skin, immune tissues, and reproductive organs, with potential roles in growth regulation, immune modulation, and epithelial differentiation.Structurally, IGFL3 is a secreted protein containing conserved cysteine residues that form disulfide bonds, stabilizing the IGF-like fold. It contains signal peptides directing secretion and motifs related to IGF binding proteins. Unlike classical IGFs, IGFL3 has limited affinity for IGF receptors, suggesting unique receptor interactions. Alternative isoforms expand potential tissue-specific functions.Functionally, IGFL3 acts as a signaling ligand influencing epithelial proliferation, immune responses, and reproductive biology. It has been shown to modulate keratinocyte growth and survival, supporting roles in skin homeostasis. In immune tissues, IGFL3 may influence T-cell differentiation and cytokine responses. Although mechanistic pathways remain incompletely understood, IGFL3 is considered a growth and differentiation factor with specialized activity. Researchers use IGFL3 antibody to explore growth factor biology, immune regulation, and tissue development.Clinically, IGFL3 has been linked to psoriasis and autoimmune conditions, where dysregulated expression affects skin and immune homeostasis. It may also play roles in fertility and embryonic development. Studies continue to investigate whether IGFL3 participates in cancer progression by promoting epithelial proliferation. NSJ Bioreagents supplies IGFL3 antibody to support investigations into growth factor signaling, skin biology, and immunology.Experimentally, IGFL3 antibody is applied in western blotting to detect secreted and intracellular forms, in immunohistochemistry to study tissue distribution, and in ELISA to quantify secreted protein in serum or conditioned media. Co-immunoprecipitation with IGFL3 antibody helps identify receptor interactions and signaling partners.